Diagnostic Algorithms in Renal Biopsy Interpretation Along with Case Samples

Kidney has three main histological compartments including glomerular, vascular and tubulointerstitial. First, an approach should be performed to localize in which department the main injury occurs and to recognize the severity and extent of the renal injury in each department. Then, the type of injury is to be assessed such as active versus chronic. Active lesions includes cellular proliferation, crescents, edema, necrosis and acute inflammation while chronic lesions represent fibrosing conditions such as fibrous crescents, interstitial fibrosis, glomerulosclerosis, tubular atrophy or vascular sclerosis. (Walker, 2004, 2009; Kretzler, 2002; Fogo, 2003)